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KMID : 0377619630050060651
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Korean Jungang Medical Journal
1963 Volume.5 No. 6 p.651 ~ p.663
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Studies on the Mechanism of Immunity Induced by Living Cultures of B.C.G. in Experimental Tuberculosis of Mice
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Abstract
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Establishment of tuberculous infection is closely related with multiplication of tubercle bacilli in vivo and the virulence of tubercle bacilli goes parallel to multiplication in vivo.
Immunity in tuberculosis being an anti-bacterial immunity, the establishment of tuberculosis immunity in a individual or in a certain organ and the grade there-of, therefore, goes parallel to acquisition of inhibition power on in vivo mulitiplication of the infecting bacteria and the grade there-of.
From this point of view the Author studied organ specifity and the mechanisms involved in establishment of immunity produced by the living B.C.G. in mice through quantitative cultivation method of tubercle bacilli making at the same time a critical reevaluation on various theories concerning the main factors in tuberculosis immunity and reached at the following conclusions.
1) In mice multiplication of B.C.G. in various organs has a organ specificity failing completely to grow especially in lung and kidney, and in spleen it fell after making an initial increase.
2) Though the immunogenic effect to challenge´_ bacteria was found to be higher, the more were the number of living B.G.G. in various organs, the difference in anti-bacterial effect was not as big as compared with that in the number of living B.C.G.
3) Anti-bacterial immunogenic effect was found to be equal between the group in which in vivo growth of B.C.G. was inhibited by INH-treatment and the nonINH-treatal immunized group, reflecting the point that the growth of B.C.G. is not indispensible for the establishment of the immilnity and grade there-of.
4) INH is presumed to have bactericidal action to B.C.G. in vivo and it causes decrease in number of living B.C.G. only when administered early in the immunization process.
5) The lung is considered to be more suitable organ than the spleen for criteria of immunogenic effect in mice.
6) Author wishes to present "host-organ-parasite relationship" based an organ specificity as a factor in the establishment of tuberculosis immunity.
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